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Motrin (Ibuprofen) associated with GI complications: Doctor's Guide: "BOSTON, MA -- June 17, 1999 -- In a review article published in this week's issue of The New England Journal of Medicine, Boston University School of Medicine (BUSM) researchers discussed significant and potentially fatal side-effects of nonsteroidal anti-inflammatory drug (NSAID) use. NSAIDs include medications such as aspirin, ibuprofen (Advil, Motrin), naproxen sodium (Aleve, Naprosyn, Naprox), diclofenac (Voltaren), indomethacin (Indocin), and many others. M. Michael Wolfe, MD, professor of medicine at BUSM and chief of the section of gastroenterology in the department of medicine at Boston Medical Center led the study. "This is, in many ways, a silent epidemic because gastrointestinal complications are not preceded by any warning signs in a majority of individuals," Wolfe said."
http://www.docguide.com/news/content.nsf/news/7B98289A5A1F59B4852567930049E008?OpenDocument&id=48DDE4A73E09A969852568880078C249&count=10&highlight=0,

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Motrin (Ibuprofen) concerns and side effects : Health Square: "More common side effects may include: Abdominal cramps or pain, abdominal discomfort, bloating and gas, constipation, diarrhea, dizziness, fluid retention and swelling, headache, heartburn, indigestion, itching, loss of appetite, nausea, nervousness, rash, ringing in ears, stomach pain, vomiting Less common or rare side effects may include: Abdominal bleeding, anemia, black stool, blood in urine, blurred vision, changes in heartbeat, chills, confusion, congestive heart failure, depression, dry eyes and mouth, emotional volatility, fever, hair loss, hearing loss, hepatitis, high or low blood pressure, hives, inability to sleep, inflammation of nose, inflammation of the pancreas or stomach, kidney or liver failure, severe allergic reactions, shortness of breath, skin eruptions or peeling, sleepiness, stomach or upper intestinal ulcer, ulcer of gums, vision loss, vomiting blood, wheezing, yellow eyes and skin"
http://www.healthsqr.com/newrx/MOT1276.HTM

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Motrin (Ibuprofen) (childrens advil suspension) : University of Iowa Nursing: "Action: Inhibits prostaglandin synthesis by decreasing enzyme needed for biosynthesis, Therapeutic effect: Suppression of pain and inflammation. Reduction of fever.Use: Fever, mild to moderate pain, rheumatoid arthritis, Osteoarthritis, Primary Dysmenorrhea, Gout, dental pain, Musculoskeletal disorder.Onset: 30 minutes, anti inflammatory onset may require seven daysPeak Plasma concentrations: 1-2 hrs90%-99% plasma protein binding , does not enter breast milkSteady state: Partial arthritic relief is usually seen within 7 days but maximum effectiveness may require 1-2 weeks of continuous therapy of Ibuprofen.Metabolism: Metabolized in liver (inactive metabolites), excreted in urine.Half Life: 2-4 hrs"
http://www.nursing.uiowa.edu/sites/adultpain/NSAIDS/ibuprot.htm

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Overdose information Motrin (Ibuprofen) examples, contraindications : Rx List: "Approximately 1½ hours after the reported ingestion of from 7 to 10 ibuprofen tablets (400 mg), a 19-month old child weighing 12 kg was seen in the hospital emergency room, apneic and cyanotic, responding only to painful stimuli. This type of stimulus, however, was sufficient to induce respiration. Oxygen and parenteral fluids were given; a greenish-yellow fluid was aspirated from the stomach with no evidence to indicate the presence of ibuprofen. Two hours after ingestion the child's condition seemed stable; she still responded only to painful stimuli and continued to have periods of apnea lasting from 5 to 10 seconds. She was admitted to intensive care and sodium bicarbonate was administered as well as infusions of dextrose and normal saline. By four hours post-ingestion she could be aroused easily, sit by herself and respond to spoken commands. Blood level of ibuprofen was 102.9 mcg/ml, approximately 8½ hours after accidental ingestion. At 12 hours she appeared to be completely recovered."
http://www.rxlist.com/cgi/generic/ibup_od.htm

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Children's Motrin (Ibuprofen) Product information: Kid Source: "Children's Motrin drops and caplets will offer parents new choices in ibuprofen therapy for children of different weights end ages," said Laura Popper, M.D., a leading New York City pediatrician and author on children's health. "It's an important benefit for parents to have a range of options available to treat their children's fever end pain."Children's Motrin will be the only OTC pediatric ibuprofen available in liquid suspension, drops and solid dosage formulations. The product line is indicated for use in children between the ages of two to 11 years. It lasts up to eight hours to reduce fever and relieve pain due to colds, flu, sore throat, headaches and toothaches. Children's Motrin Drops provide a more accurate end convenient way to dose younger children. Junior Strength Motrin Caplets are smaller than adult medications and are an ideal choice for older children who can't swallow an adult-sized pill."
http://www.kidsource.com/kidsource/content/news/motrin6_29_96.html

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Hear what this mother and others are saying about Motrin (Ibuprofen) : epinions user tnt8: "My son was recovering recently from a bilateral hernia repair with work done also to one testicle. He was in a lot of pain, which can be expected after the surgery, and later development of an infection. He was prescribed Tylenol with codeine at first but this can only be taken every eight hours and was affective for only about four. Our Pediatrician prescribed Motrin concentrated infant drops to be used in a rotation with the Tylenol. Every four hours we would give the opposite drug. Tylenol with codeine- four hours later Motrin- four hours later Tylenol with codeine. This was effective in reducing his pain but when given only Motrin the pain was not relieved for long."
http://www.epinions.com/content_43687382660

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Rare side effects of Motrin (Ibuprofen): Natural Essentials: "Less common or rare side effects may include: Abdominal bleeding, anemia, black stool, blood in urine, blurred vision, changes in heatbeat, chills, confusion, congestive heart failure, eepression, dry eyes and mouth, emotional volatitity, fever, hair loss, hearing loss, hepatitis, high or low blood pressure, hives, inability to sleep, inflammation of nose, inflammation of the pancreas or stomach, kidney or liver failure, servere allergic reactions, shortness of breath, skin eruptions or peeling, sleepiness, stomach or upper intestinal ulcer, ulcer of gums, vision loss, vomiting blood, wheezing, yellow eyes and skin."
http://www.naturalessentials.com/motrin.htm

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Drug interactions for Motrin (Ibuprofen): Focus on Arthritis: "Ibuprofen should be avoided by patients with a history of asthma attacks, hives or other allergic reactions to aspirin or other NSAIDs. Rare but severe allergic reactions have been reported in such individuals. It also should be avoided by patients with peptic ulcer disease or poor kidney function, since this medication can aggravate both conditions. Ibuprofen is generally used with caution in patients taking blood thinning medications (anticoagulants), such as warfarin (Coumadin), because of an increased risk of bleeding. Patients taking lithium can develop toxic blood lithium levels. Children's Advil and Children's Motrin are approved for use in children, 6 months and older, to treat fever, pain, and symptoms of arthritis. Ibuprofen is not habit forming. NSAIDs should be discontinued prior to elective surgery because of a mild interference with clotting that is characteristic of this group of medicines. Ibuprofen is best discontinued at least two days in advance of the procedure."
http://www.focusonarthritis.com/script/main/art.asp?articlekey=792

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