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This page was prepared by Lynn Kash, RN, Internet Nursing Guide
Pennsylvania Nurses,Emergency Department
http://www.nursefriendly.com/kash/

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Estradiol Transdermal(Vivelle-dot), Business Summary, Business Week Online:"The company's principal products are Vivelle (Menorest outside the U.S. and Canada) and Vivelle-Dot prescription transdermal estrogen patches, which are used in female hormonal replacement therapy. Vivelle and Vivelle-Dot have been licensed for sale in the U.S. by Novogyne (a partnership between Noven and Novartis). Novartis has also licensed from Noven rights to sell Vivelle-Dot in all areas outside of the U.S. except Japan. Novartis currently sells Vivelle-Dot under the Estradot name in Europe. These products are used primarily to replace estrogen in hysterectomized women. Aventis has marketing rights to Vivelle-Dot in Japan."
http://research.businessweek.com/business_summary.asp?Symbol=NOVN

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Estradiol Transdermal(Vivelle-dot), General Information, Center Watch:"Vivelle-Dot has been approved by the FDA for the prevention of post-menopausal osteoporosis. This estrogen replacement therapy is currently marketed for the treatment of menopausal symptoms. Vivelle-Dot is a smaller, revised version of the original Vivelle transdermal product, which was approved in 2000. Vivelle-Dot is designed to deliver estradiol, the primary estrogen produced by the ovaries, via a small patch that is applied twice weekly. The product utilizes Noven's DOT Matrix transdermal drug delivery technology to effectively deliver the drug through the small patch surface area. DOT Matrix patches use ratios of silicone, acrylic and drug to regulate the rate of delivery through the skin and into the bloodstream."
http://www.centerwatch.com/patient/drugs/dru781.html

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Estradiol Transdermal(Vivelle-dot), Vivelle-Dot Available In The U.S. For Menopause Symptoms, May 10, 1999, Doctor's Guide:"Like the original Vivelle(R) (estradiol transdermal system), Vivelle-Dot is available in four dosage strengths (.0375, .05, .075 and .10 mg/day), and provides prescribing physicians with broad dosing flexibility. In the most commonly prescribed dosage strength (.05 mg/day), Vivelle-Dot is about the size and thickness of a postage stamp."
http://www.pslgroup.com/dg/fc87a.htm

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Estradiol Transdermal(Vivelle-dot), Different forms of HRT, EarlyMenopause.com:"These are all the newer improved estrogen patches. Like the reservoir patches that were first designed, thest patches continuously release natural, bio-identical estrogen into your system, but they tend to cause less skin irritation. According to one manufacturer, only about 9 percent of users developed significant skin irritation -- about half that of Estraderm reservoir patch users. The matrix patch was first introduced in 1995, when the Climara patch came out. A year later, the makers of the Estraderm patch came out with their version of a matrix patch, Vivelle. Next came Fempatch, a lower dose estrogen patch. And most recently Vivelle came out with a new super-tiny patch -- the Vivelle dot, about the size of a nickel or postage stamp."
http://www.earlymenopause.com/hrt_climara.htm

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Estradiol Transdermal(Vivelle-dot), What is this medication used for, Health and Age:"This medicine is used to stop/reduce the symptoms of menopause, especially hot flashes, vaginal dryness, itching, or burning. It helps help prevent osteoporosis (brittle bones; can lead to breaks) in women past menopause. This medicine works best when used with calcium/vitamin D supplements, weight-bearing exercises like walking, or physical therapy. May also be used to lower high cholesterol in women who have gone through menopause. It may be used vaginally as a cream to treat irritation and itching in the vagina caused by menopause. It is used as an estrogen replacement. It rarely is used for the treatment of certain types of cancer (breast/prostate)."
http://www.healthandage.com/html/res/com/ConsDrugs/Estradiolcd.html

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Estradiol Transdermal(Vivelle-dot), Why is this medication prescribed, Health Square:"All of these products are used to reduce symptoms of menopause, including feelings of warmth in the face, neck, and chest; the sudden intense episodes of heat and sweating known as "hot flashes"; dry, itchy external genitals; and vaginal irritation. They are also prescribed for other conditions that cause low levels of estrogen, and some doctors prescribe them for teenagers who fail to mature at the usual rate. Along with diet, calcium supplements, and exercise, Estraderm, Climara, and Vivelle are prescribed to prevent osteoporosis, a condition in which the bones become brittle and easily broken. Climara may also be used to treat certain types of abnormal bleeding from the uterus."
http://www.healthsquare.com/newrx/est1165.htm

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Estradiol Transdermal(Vivelle-dot), What is the most important information I should know about estradiol topical patches, Laurus Health:"Estradiol topical patches increase the risk of developing a condition (endometrial hyperplasia) that may lead to cancer of the lining of the uterus. Taking progestins, another hormone drug, while using estradiol topical patches lowers the risk of developing this condition. Therefore, if your uterus has not been removed, your doctor may prescribe a progestin for you to take together while using estradiol topical patches. Visit your doctor regularly and report any unusual vaginal bleeding right away."
http://www.laurushealth.com/Library/HealthGuide/DrugGuide/topic.asp?hwid=multumd00537t1

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Estradiol Transdermal(Vivelle-dot), World's Smallest Estrogen Patch, Novartis Pharmaceuticals:"Vivelle-Dot® is indicated for the treatment of the symptoms of menopause and the prevention of postmenopausal osteoporosis. It is now available in five dosage strengths (.025, .0375, .05, .075 and .10 mg/day) with the .025 dosage strength indicated for the prevention of postmenopausal osteoporosis only. These five strengths provide prescribing physicians with broad dosing flexibility. In the most commonly prescribed dosage strength (.05 mg/day), Vivelle-Dot® is about the size and thickness of a postage stamp. By area, it is about one-third the size of Climara® (Berlex) and about one-quarter the size of Estraderm® (Novartis)."
http://www.noven.com/vivelledot.htm

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Estradiol Transdermal, Why is this drug prescribed, PDR.net:"All of these products are used to reduce symptoms of menopause, including feelings of warmth in the face, neck, and chest; the sudden intense episodes of heat and sweating known as "hot flashes"; dry, itchy external genitals; and vaginal irritation. They are also prescribed for other conditions that cause low levels of estrogen, and some doctors prescribe them for teenagers who fail to mature at the usual rate. Along with diet, calcium supplements, and exercise, Estraderm, Climara, and Vivelle are prescribed to prevent osteoporosis, a condition in which the bones become brittle and easily broken. Climara may also be used to treat certain types of abnormal bleeding from the uterus."
http://www.gettingwell.com/drug_info/rxdrugprofiles/drugs/EST1165.shtml

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Estradiol Transdermal(Vivelle-dot), Estrogen Crash-Treating Early Menopause, What You Need To Know About Women's Health:"The smallest of these patches is Vivelle-Dot™. The .05 mg/day dose is the size of a postage stamp and about 75% smaller than average estrogen patches. It is worn on the lower abdomen where it delivers estradiol through a transdermal skin patch into the bloodstream. Estradiol is the primary estrogen produced by the ovaries. Vivelle-Dot is changed twice weekly and lasts through showers, swimming, and other daily activities without coming off. The patch provides relief from hot flashes, night sweats, and other symptoms of Estrogen Crash or natural menopause http://womenshealth.about.com/library/weekly/aa072000a.htm

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