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Latanoprost(Xalatan), About Xalatan, Xalatan.com:"XALATAN is a prescription eye drop for the reduction of intraocular pressure (IOP) in patients who suffer from open-angle glaucoma or ocular hypertension*. While the causes of glaucoma are still unknown, elevated IOP is the primary treatable risk factor associated with the disease. Studies suggest that lowering IOP slows the likelihood of disease progression."
http://www.xalatan.com/health_pro/

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Latanoprost, Indications, RXlist:"Latanoprost is indicated for the reduction of elevated intraocular pressure in patients with open-angle glaucoma and ocular hypertension who are intolerant of other intraocular pressure lowering medications or insufficiently responsive (failed to achieve target IOP determined after multiple measurements over time) to another intraocular pressure lowering medication."
http://www.rxlist.com/cgi/generic/latanoprost_ids.htm

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Latanoprost(Xalatan), Xalatan (Latanoprost) Reduces Intraocular Eye Pressure Better Than Trusopt (Dorzolamide), October 17, 2000, Doctor's Guide:"-- In a study published in the British Journal of Ophthalmology Xalatan® (latanoprost ophthalmic solution) 0.005% once daily provided a significantly greater reduction of intraocular eye pressure (IOP) than Trusopt® (dorzolamide hydrochloride ophthalmic solution) 2.0% three times daily."
http://www.pslgroup.com/dg/1e4bd2.htm

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Latanoprost, Precautions, MEDLINEplus:"While you are using latanoprost, the iris (colored part) of your treated eye(s) may slowly become more brown in color . This is more likely to happen if you have blue-brown, gray-brown, green-brown, or yellow-brown eyes. The change in color of the iris is noticeable usually within several months or years from the start of treatment with latanoprost. In addition, there may be a darkening of eyelid skin color. Also, your eyelashes may become longer, thicker, and darker. These changes to the iris, eyelid, and lashes may be permanent even if you stop using latanoprost. Also, these changes to the iris, eyelid, and lashes will affect only the eye being treated with latanoprost. Therefore, if only one eye is being treated, only that eye may develop darker iris, eyelid, and eyelashes and other changes to the eyelashes, and you may have differently appearing eyes . Check with your doctor if you have any questions about this."
http://www.nlm.nih.gov/medlineplus/druginfo/latanoprostophthalmic203607.html

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Latanoprost(Xalatan), Most important fact, PDR.net:"Be careful not to let the tip of the Xalatan bottle touch your eye or anything else. Otherwise, the contents could become contaminated. A contaminated solution can cause an eye infection and lead to serious damage, including loss of vision."
http://www.gettingwell.com/drug_info/rxdrugprofiles/drugs/XAL1490.shtml

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Latanoprost, Dosing, Medicine Net:"The hands should be washed before each use of latanoprost or any eye medication. The head is tilted back and the lower eyelid is pulled down with the index finger to form a pouch. (It is important not to touch the tip of the dropper to the eye or the eyelid so that bacteria are not introduced into the bottle.) The bottle is squeezed slightly to allow the prescribed number of drops into the pouch. The eye then is closed gently for 2 to 3 minutes without blinking. The usual dose is one drop into the affected eye once daily."
http://www.focusonmedications.com/Script/Main/Art.asp?li=MNI&ArticleKey=6741

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Latanoprost, How it works, Whole Health MD:"Glaucoma, a sight-threatening disorder, occurs when the aqueous humor (fluid inside the eye) cannot drain properly, causing increased pressure within the eyeball (intraocular pressure). Increased eye pressure can damage the optic nerve and lead to a gradually progressive loss of vision. Latanoprost promotes outflow of aqueous humor, thereby reducing intraocular pressure."
http://www.wholehealthmd.com/refshelf/drugs_view/0,1524,657,00.html

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Latanoprost, Adverse Reactions, Saunders Nursing Drug Handbook:"Systemic events produce upper respiratory tract infection/cold/flu (4%), and rarely, musculoskeletal pain, chest pain, angina pectoris, allergic skin reaction (1-2%)."
http://www.us.elsevierhealth.com/SIMON/SaundersNDH/latanoprost.html

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Latanoprost, Clinical Pharmacology, Mosby's DRUG Consult:"Latanoprost is a prostanoid selective FP receptor agonist which is believed to reduce the intraocular pressure by increasing the outflow of aqueous humor. Studies in animals and humans suggest that the main mechanism of action is increased uveoscleral outflow."
http://www.mosbysdrugconsult.com/genrxfree/Top_200_1999/Drugs/E3299.htm

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