Nursing & Healthcare Directories on: The Nursefriendly
Prescription Drugs, Medications
Cancer Oncology, Chemotherapy, Anticancer,
Leukovorin Calcium, Leucovorin

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Pennsylvania Nurses,Emergency Department
http://www.nursefriendly.com/kash/

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Leukovorin Calcium, Action, American Cancer Society:"Leucovorin calcium can do two things. First, it helps drugs such as 5-fluorouracil work better than the 5-fluorouracil can alone (potentiates). This makes the 5-fluorouracil kill cancer cells more effectively. Second, it can rescue normal cells from the action of methotrexate. This allows cells lining the mouth and gastrointestinal tract, and the cells in the bone marrow to be less affected by the methotrexate. It is an antidote when used this way, and MUST be taken exactly as directed. Otherwise, the body will have severe side effects from the methotrexate."
http://www.cancer.org/eprise/main/docroot/CDG/content/CDG_leucovorin_calcium?internal=1

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Leukovorin Calcium, Description, Associated Hospital Service:"Leucovorin calcium counteracts the toxic effects of folic acide antagonists such as methotrexate (MTX) and can potentiate the chemotherapeutic effects of fluoropyrimidines like 5-flourouracil (5-FU) used to treat advanced colorectal, head and neck, squamous cell, gastric, hepatic and breast carcinomas."
http://www.ahsmedicare.com/medical_review_appeals/provider/LMRP/Rescinded/p9628.shtml

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Leukovorin Calcium, How does this medication work, MedBroadcast.com:"Leucovorin is a medication that acts the same way in the body as folic acid. Leucovorin is used to reduce the folic-acid-lowering side effects of methotrexate because it is not affected by methotrexate in the same way as folic acid is. It is also used to treat a condition known as megaloblastic anemia, which is an anemia that can be caused by sprue (a condition resulting from reduced absorption of nutrients from the stomach into the bloodstream) and that can occur during pregnancy and infancy. Leucovorin is also used in combination with fluorouracil to treat cancer of the colon."
http://drugs.medbroadcast.com/ASP/DrugInfo.asp?BrandNameID=1429

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Leukovorin Calcium, About your treatment, MEDLINEplus:"Leucovorin is a vitamin derivative. When used in combination with fluorouracil, it enhances the ability of the chemotherapy to slow or stop the growth of cancer cells in your body. In diseases where the amount of folate is low, it can replace the body's supply of the vitamin. Leucovorin also can prevent or treat the toxicities associated with a group of drugs known as folate antagonists. The length of treatment depends on the types of drugs you are taking, how well your body responds to them, and the type of disease you have."
http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a682336.html

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Leukovorin Calcium, Indications, RXlist:"Leucovorin calcium rescue is indicated after high­dose methotrexate therapy in osteosarcoma. Leucovorin is also indicated to diminish the toxicity and counteract the effects of impaired methotrexate elimination and of inadvertent overdosages of folic acid antagonists."
http://www.rxlist.com/cgi/generic2/leucovorin_ids.htm

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Leukovorin Calcium, Description, Space Coast Medical Associates:"Leucovorin Calcium or folic acid is a B-vitamin used to decrease the harmful blood effects of different medications such as methotrxate, Trimetrexate, and pyrimethamine. Leucovorin Calcium may also be used to treat some kinds of anemia. Leucovorin Calcium is also given along with a 5-fluorouracil (a medication for cancer) to treat cancer, such as cancers of the colon or large intestine."
http://www.spacecoastmedicalassociates.com/chemotherapy/leucovorincalcium.htm

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