Nursing & Healthcare Directories on: The Nursefriendly
Prescription Drugs, Medications
Aromatase Inhibitors, Breast Cancer Chemotherapy,
Fulvestrant, Faslodex

The Shortcut URL To This Page Is http://www.prescriptionforviagra.com/faslodex/

This page was prepared by Lynn Kash, RN, Internet Nursing Guide
Pennsylvania Nurses,Emergency Department
http://www.nursefriendly.com/kash/

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Fulvestrant, Classification, American Cancer Society:"Fulvestrant belongs to a new group of drugs called estrogen receptor downregulators. It is used as a treatment for advanced breast cancer in postmenopausal women who no longer respond to anti-estrogens like tamoxifen."
http://www.cancer.org/eprise/main/docroot/CDG/content/CDG_fulvestrant?internal=1

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Fulvestrant (Faslodex), General Information, Center Watch:"AstraZeneca's Faslodex has been approved for the treatment of hormone receptor positive metastatic breast cancer. It is indicated for use in postmenopausal women whose disease has progressed after receiving anti-estrogen therapy (such as tamoxifen). The therapy is given as a once-a-month intramuscular injection."
http://www.centerwatch.com/patient/drugs/dru775.html

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Fulvestrant (Faslodex), Faslodex(R) (fulvestrant) Advanced Breast Cancer Treatment Data Presented In Journal of Clinical Oncology, August 14, 2002, Doctor's Guide:"Faslodex provides a new choice for patients progressing following tamoxifen therapy," said C. Kent Osborne, M.D., Baylor College of Medicine, Houston, Texas. "This published data, comparing Faslodex to an aromatase inhibitor, allows physicians to become better informed about Faslodex as a viable treatment option for postmenopausal women with advanced breast cancer."
http://www.pslgroup.com/dg/21b2c6.htm

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Fulvestrant (Faslodex), How Does it Work, Drug Digest:"Many breast cancers have estrogen receptors (a cell that will combine with a drug, hormone, or chemical to alter the function of the cell) and the growth of these tumors can be stimulated by estrogen. Fulvestrant is an estrogen receptor antagonist (counteract the action of something else) that binds to the estrogen receptor and prevents or inhibits the release of estrogens."
http://www.drugdigest.org/DD/DVH/MOA/0,8635,551152|Fulvestrant,00.html

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Fulvestrant (Faslodex), Food and Drug Administration Approves Additional Breast Cancer Therapy, April 26, 2002, InteliHealth.com:"The Food and Drug Administration on Thursday approved an additional therapy for advanced breast cancer patients whose disease continues to progress following other treatment. Faslodex was approved for use in post-menopausal women with a type of cancer known as hormone receptor positive metastatic breast cancer, the FDA said. Faslodex is intended for women whose cancer continues despite anti-estrogen therapy such as tamoxifen."
http://www.intelihealth.com/IH/ihtIH/WSIHW000/333/7228/349267.html

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Fulvestrant (Faslodex), Mechanism of Action, Mosby's DRUG Consult:"Many breast cancers have estrogen receptors (ER), and the growth of these tumors can be stimulated by estrogen. Fulvestrant is an estrogen receptor antagonist that binds to the estrogen receptor in a competitive manner with affinity comparable to that of estradiol. Fulvestrant downregulates the ER protein in human breast cancer cells. In a clinical study in postmenopausal women with primary breast cancer treated with single doses of fulvestrant 15-22 days prior to surgery, there was evidence of increasing down regulation of ER with increasing dose. This was associated with a dose-related decrease in the expression of the progesterone receptor, an estrogen-regulated protein. These effects on the ER pathway were also associated with a decrease in Ki67 labeling index, a marker of cell proliferation." http://www.mosbysdrugconsult.com/DrugConsult/003553.html

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Fulvestrant (Faslodex), New Treatment Option for Advanced Breast Cancer, National Cancer Institute:"A new drug called fulvestrant (Faslodex®) was as effective as another drug, anastrozole (Arimidex®), in postmenopausal women with advanced, previously treated breast cancer, according to two studies published in the August 15, 2002, issue of the Journal of Clinical Oncology. It is too soon to say, however, whether patients treated with fulvestrant live longer than those treated with anastrozole."
http://www.nci.nih.gov/clinicaltrials/results/fulvestrant0802

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Fulvestrant (Faslodex), Side Effects, NursingDrugGuide.com:"Common: headache, nausea, vomiting, dizziness, reactions at the injection site, hot flashes, constipation or diarrhea, bone pain, increased cough, shortness of breath.Less common: depression, water retention, flulike symptoms, anxiety, insomnia, anemia, urinary tract infection."
http://www.nursingdrugguide.com/pt_usingfulvestrantfaslodex.htm

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